I’m unable to upload on my instance 2 to 3 GB files. I got a 500 internal Server Error when reaching the third of the uploaded files. Log isn’t very informative or I don’t know how to interpret it 
Solved! It was a temporary directory problem on the reverse proxy server. I had to set client_body_temp_path parameter to another folder in nginx.
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Thanks!
See https://github.com/Chocobozzz/PeerTube/issues/1423 for the others